01 - Heat a large skillet over medium-high heat. Add ground beef and season with salt, pepper, garlic powder, and onion powder. Cook while breaking up the meat until browned and cooked through, approximately 6-8 minutes. Drain excess fat if necessary.
02 - In a small bowl, whisk together mayonnaise, ketchup, mustard, white vinegar, pickle relish, and smoked paprika until smooth and well combined. Set aside until ready to serve.
03 - Divide chopped lettuce evenly among four serving bowls. Arrange cherry tomatoes, sliced red onion, shredded cheddar cheese, and pickle slices on top of the lettuce.
04 - Spoon the cooked ground beef evenly over each salad bowl, distributing it across the prepared vegetables and cheese.
05 - Drizzle each bowl generously with the prepared burger sauce. Top with sliced avocado, crumbled bacon, and a sprinkle of sesame seeds if desired. Serve immediately while the beef is still warm.